Euphorbia pekinensis glycosphingolipids disrupt gut motility and fluid balance via TRPA1 activation in enterochromaffin cells

This research reveals that the gut toxicity of EP is driven by a previously unrecognized GSL-TRPA1-5-HT signalling pathway in the intestinal epithelium. These findings provide a clear mechanistic basis for EP-induced diarrhoea and highlight a potential new target for managing gut toxicity.