作者
Ying Zhang,Yong Niu,Zhijie Han,Qi Yu,P. F. He,Xue Li,S. X. Zhang
摘要
Background
Gout is a prevalent and painful inflammatory arthritis. Increasingly studies have shown that the gut microbiota is associated with gout [1-3]. However, whether these associations reflect a causal relationship is still being determined. Objectives
To investigate whether there is a causal relationship between intestinal bacteria and gout, we used Mendelian randomization (MR) two-sample analysis. Methods
Gout-related data were derived from the Integrated Epidemiology Unit (IEU) GWAS database, which included 2115 gout cases and 67259 controls [4]. The data on intestinal bacteria came from the website MRbase. We searched 173 species of bacteria and finally identified 5 genus species, which were the Eubacterium brachy, Eubacterium hallii, Howardella, Sellimonas, and order Mollicutes RF9. MR-Egger, weighted median, inverse variance weighting (IVW), and MR-PRESSO were used to conduct the double-sample MR analysis. Finally, we excluded the data related to poly-effect and heterogeneity to ensure the robustness of the results. Results
Five kinds of gut microbiota (Eubacterium brachy, Eubacterium hallii, Howardella, Sellimonas, and order Mollicutes RF9) had a causal relationship with gout. According to inverse variance weighted estimation, Eubacterium hallii(odds ratio(OR) = 1.660, 95% confidence interval(CI): 1.073-2.569, P = 0.023), Howardella(OR = 1.391, 95% CI: 1.058-1.828, P = 0.018) and Sellimonas(OR = 1.384, 95% CI: 1.009-1.897, P = 0.044) were risk factors for gout. Eubacterium brachy(OR = 0.656, 95% CI: 0.469-0.917, P = 0.014) and order Mollicutes RF9(OR = 0.641, 95% CI: 0.471-0.874, P = 0.005) showed protective effect against gout (Figure 1). Conclusion
This study suggested a causal relationship between these five gut microbiota and gout, providing new implications for future clinical trials on the association between microbiota and gout. References
[1]Wang, Z., et al., Gut microbiota remodeling: A promising therapeutic strategy to confront hyperuricemia and gout. Front Cell Infect Microbiol, 2022. 12: p. 935723. [2]Chu, Y., S. Sun, and Y. Huang, Metagenomic analysis revealed the potential role of gut microbiome in gout. 2021. 7(1): p. 66. [3]Méndez-Salazar, E.O., Uric acid extrarenal excretion: the gut microbiome as an evident yet understated factor in gout development. NPJ Biofilms Microbiomes, 2022. 42(3): p. 403-412. [4]Köttgen, A., et al., Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Rheumatol Int, 2013. 45(2): p. 145-54. Acknowledgements:
NIL. Disclosure of Interests
None Declared.