孟德尔随机化
医学
危险系数
生命历程法
优势比
体质指数
内科学
比例危险模型
人口学
置信区间
遗传学
基因型
生物
遗传变异
心理学
基因
社会心理学
社会学
作者
Xinyu Wang,Zhiyu Wu,Jun Lv,Canqing Yu,Dianjianyi Sun,Pei Pei,Ling Yang,Iona Y. Millwood,Robin G. Walters,Yiping Chen,Huaidong Du,Mingqiang Yuan,Dan Schmidt,M. Barnard,Junshi Chen,Zhengming Chen,Liming Li,Yuanjie Pang
出处
期刊:Obesity
[Wiley]
日期:2023-10-23
卷期号:31 (12): 3077-3085
被引量:1
摘要
Abstract Objective There is little evidence on the genetic associations between life‐course adiposity (including birth weight, childhood BMI, and adulthood BMI) and severe liver disease (SLD; including cirrhosis and liver cancer). The current study aimed to examine and contrast these associations. Methods Genetic variants were obtained from genome‐wide association studies. Two‐sample Mendelian randomization (MR) analyses were performed to assess the genetic associations of life‐course adiposity with SLD and liver biomarkers. Cox regression was used to estimate adjusted hazard ratios for SLD associated with genetic risk scores of life‐course adiposity and adulthood weight change in the China Kadoorie Biobank. Results In observational analyses, genetic predispositions to childhood adiposity and adulthood adiposity were each associated with SLD. There was a U‐shaped association between adulthood weight change and risk of SLD. In meta‐analyses of MR results, genetically predicted 1‐standard deviation increase in birth weight was inversely associated with SLD at a marginal significance (odds ratio: 0.81 [95% CI: 0.65–1.00]), whereas genetically predicted 1‐standard deviation higher childhood BMI and adulthood BMI were positively associated with SLD (odds ratio: 1.27 [95% CI: 1.05–1.55] and 1.79 [95% CI: 1.59–2.01], respectively). The results of liver biomarkers mirrored those of SLD. Conclusions The current study provided genetic evidence on the associations between life‐course adiposity and SLD.
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