医学
白斑
头颈部
临床试验
头颈部癌
癌症
重症监护医学
人口
皮肤病科
内科学
外科
环境卫生
作者
James C. Gates,Marianne Abouyared,Yelizaveta Shnayder,D. Gregory Farwell,Andrew T. Day,Faizan Alawi,Michael G. Moore,Andrew J. Holcomb,Andrew C. Birkeland,Joel Epstein
出处
期刊:Head & neck
[Wiley]
日期:2024-11-25
卷期号:47 (2): 733-741
被引量:11
摘要
ABSTRACT Background Oral potentially malignant disorders (OPMDs) occur in up to 4%–5% of the population, of which oral leukoplakia (OL) is the most common subtype. Predicting high‐risk OL remains a challenge. Early diagnosis and effective treatment are thought to be of paramount importance to improve outcomes. Methods We searched PubMed and Clinicaltrials.gov data for updates in the clinical management of OL from 2015 to current. Results Recent publication of large cohorts of patients with OL aids in counseling patients regarding risk of malignant transformation. Management for OL includes surveillance, excision, and laser surgery, as well as local and systemic approaches to chemoprevention. Several new entities show promise regarding candidate biomarkers, chemoprevention agents, and diagnostic adjuncts, though all require further validation. Conclusion This update serves to further inform clinical management of OL and provide impetus for future investigations. Trial Registration NCT00099021, NCT00951379, NCT05727761, NCT05727761
科研通智能强力驱动
Strongly Powered by AbleSci AI