Synthesis and Antibacterial Properties of New Quinazoline Analogs Catalyzed by Chloroacetic Acid–Immobilized Nanocobaltferrite

ABSTRACT In this research, an effective procedure for the one‐pot construction of new quinazoline analogs using chloroacetic acid – immobolized nanocobaltferrite (nano‐CoFe 2 O 4 @SiO 2 @CPTES‐[(Ph₂PCH₂)₂‐CH 2 CO 2 H] 2+ 2Cl − ) as an efficient novel magnetic nanocatalyst under ultrasound irradiation at 80°C was presented. Chloroacetic acid–immobilized nanocobferrite was characterized by FT‐IR, XRD, FE‐SEM, TEM, EDX, TGA, VSM, and ICP‐mass analyses. Furthermore, the nanocatalyst could be comfortably isolated via magnetic attraction and recycled at least five times without remarkable loss of its catalytic activity. Additionally, in this protocol, quinazoline analogs were screened for their antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus . The results showed that quinazolines 4a , 4b , 4c , 4d , and 4g had good antibacterial activity toward Pseudomonas aeruginosa and Staphylococcus aureus .