β-catenin repositions over time

How β-catenin, the nuclear activator of the Wnt pathway, affects the chromatin environment of its targets is unknown. Over a time course of stimulation, β-catenin repositions itself around the genome in a cell-type-specific manner, eliciting transient chromatin changes in differentiated cells and progressive shaping of undifferentiated cells. How β-catenin, the nuclear activator of the Wnt pathway, affects the chromatin environment of its targets is unknown. Over a time course of stimulation, β-catenin repositions itself around the genome in a cell-type-specific manner, eliciting transient chromatin changes in differentiated cells and progressive shaping of undifferentiated cells. The time-resolved genomic impact of Wnt/β-catenin signalingPagella et al.Cell SystemsJuly 19, 2023In BriefVia time-resolved CUT&RUN, ATAC-seq, and RNA-seq on Wnt-responding HEK293Ts and hESCs, Pagella et al. show that β-catenin binds in time- and cell-specific manners to target genes leading to activation or repression of their expression. Furthermore, β-catenin can be recruited to non-accessible chromatin regions and induce elastic or plastic chromatin behaviors. Full-Text PDF Open Access