守恒定律
统计物理学
代谢活性
计算机科学
代谢调节
代谢途径
线性响应理论
物理
生物系统
生物
量子力学
新陈代谢
凝聚态物理
核磁共振
内分泌学
酶
作者
Jumpei F. Yamagishi,Tetsuhiro S. Hatakeyama
标识
DOI:10.1103/physrevlett.131.028401
摘要
Predicting cellular metabolic states is a central problem in biophysics. Conventional approaches, however, sensitively depend on the microscopic details of individual metabolic systems. In this Letter, we derived a universal linear relationship between the metabolic responses against nutrient conditions and metabolic inhibition, with the aid of a microeconomic theory. The relationship holds in arbitrary metabolic systems as long as the law of mass conservation stands, as supported by extensive numerical calculations. It offers quantitative predictions without prior knowledge of systems.
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