医学
生物标志物
CXCL9型
急性肾损伤
泌尿系统
肾炎
趋化因子
活检
病理
内科学
趋化因子受体
炎症
生物
生物化学
作者
Dennis G. Moledina,Wassim Obeid,Rex Neal Smith,Ivy A. Rosales,Meghan E. Sise,Gilbert Moeckel,Michael Kashgarian,Michael Kuperman,Kirk N. Campbell,Sean Lefferts,Kristin Meliambro,Markus Bitzer,Mark A. Perazella,Randy L. Luciano,Jordan S. Pober,Lloyd G. Cantley,Robert B. Colvin,F. Perry Wilson,Chirag R. Parikh
摘要
Background. Acute tubulointerstitial nephritis (AIN) is one of the few causes of acute kidney injury with diagnosis-specific treatment options. However, due to the need to obtain a kidney biopsy for histological confirmation, AIN diagnosis can be delayed, missed, or incorrectly assumed. Here, we identify and validate urinary CXCL9, an IFN-γ-induced chemokine involved in lymphocyte chemotaxis, as a diagnostic biomarker for AIN.
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