A warehouse functions as a vital hub linking various departments, and its layout and management possess substantial potential for enhancement. Therefore, optimizing the warehousing structure is pivotal for enterprises to achieve success in a constantly evolving market environment. X Warehouse specializes in the production, storage, and sale of compound fertilizers and other related products. To address the inefficiencies in the layout of X Warehouse's operational areas, this paper adopts the SLP (Systematic Layout Planning) method to delineate the functional zones within the operational area. It conducts an in-depth analysis of the logistics and non-logistics relationships as well as the comprehensive interactions among these functional zones. Subsequently, a positional relationship diagram of each functional section is created. By integrating the specific conditions of the operational area, an optimized layout plan is formulated and further validated through Flexsim simulation analysis to determine the most effective scheme.