A Common CTRB misfolding variant associated with pancreatic cancer risk causes ER stress and inflammation in mice

BACKGROUND: deletion variant proposed to increase pancreatic cancer risk. OBJECTIVE: orthologue. DESIGN: ). This mutation closely mimics the human variant. Mice carrying the mutant allele were profiled at 3 months to assess their phenotype. RESULTS: exon 6 deletion variant carriers from the GTEx cohort. CONCLUSIONS: This mouse strain provides evidence that the exon 6 deletion causes ER stress and inflammation and is an excellent model to understand its contribution to pancreatic cancer and identify preventive strategies.