果蝇属(亚属)
分类
神经科学
生物
细胞生物学
解剖
沟通
计算机科学
心理学
遗传学
基因
程序设计语言
作者
Egemen Agi,Eric T. Reifenstein,Charlotte B Wit,Teresa Schneider,Monika Kauer,Melinda Kehribar,Abhishek Kulkarni,Max von Kleist,P. Robin Hiesinger
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2024-03-08
卷期号:383 (6687): 1084-1092
标识
DOI:10.1126/science.adk3043
摘要
The idea of guidance toward a target is central to axon pathfinding and brain wiring in general. In this work, we show how several thousand axonal growth cones self-pattern without target-dependent guidance during neural superposition wiring in Drosophila . Ablation of all target lamina neurons or loss of target adhesion prevents the stabilization but not the development of the pattern. Intravital imaging at the spatiotemporal resolution of growth cone dynamics in intact pupae and data-driven dynamics simulations reveal a mechanism by which >30,000 filopodia do not explore potential targets, but instead simultaneously generate and navigate a dynamic filopodial meshwork that steers growth directions. Hence, a guidance mechanism can emerge from the interactions of the axons being guided, suggesting self-organization as a more general feature of brain wiring.
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