甲状腺结节
甲状腺乳突癌
甲状腺癌
甲基化
DNA甲基化
生物
运行x1
恶性肿瘤
生物标志物
甲状腺
癌症研究
癌症
病理
内科学
肿瘤科
医学
内分泌学
基因
遗传学
基因表达
转录因子
作者
Junjie Li,Yifei Yin,Hongbiao Huang,Mengxia Li,Hong Li,Minmin Zhang,Chenxia Jiang,Rongxi Yang
出处
期刊:Epigenomics
[Future Medicine]
日期:2023-12-21
被引量:1
标识
DOI:10.2217/epi-2023-0338
摘要
Aim: It remains a challenge to accurately identify malignancy of thyroid nodules when biopsy is indeterminate. The authors aimed to investigate the abnormal DNA methylation signatures in papillary thyroid cancer (PTC) compared with benign thyroid nodules (BTNs). Methods: The authors performed genome profiling by 850K array and RNA sequencing in early-stage PTC and BTN tissue samples. The identified gene was validated in two independent case–control studies using mass spectrometry. Results: Hypomethylation of RUNX1 in PTC was identified and verified (all odds ratios: ≥1.50). RUNX1 methylation achieved good accuracy in differentiating early-stage PTC from BTNs, especially for younger women. Conclusion: The authors disclosed a significant association between RUNX1 hypomethylation and PTC, suggesting RUNX1 methylation as a potential biomarker for companion diagnosis of malignant thyroid nodules.
科研通智能强力驱动
Strongly Powered by AbleSci AI