神经退行性变
衰老
神经科学
脑老化
衰老的大脑
细胞衰老
生物
表型
病态的
老化
电池类型
细胞
生物信息学
医学
疾病
病理
细胞生物学
认知
遗传学
基因
作者
Lívia Santos,Marina Trombetta-Lima,Eggen BJL,Marco Demaria
标识
DOI:10.1016/j.arr.2023.102141
摘要
Cellular senescence is a state of terminal cell cycle arrest associated with various macromolecular changes and a hypersecretory phenotype. In the brain, senescent cells naturally accumulate during aging and at sites of age-related pathologies. Here, we discuss the recent advances in understanding the accumulation of senescent cells in brain aging and disorders. Here we highlight the phenotypical heterogeneity of different senescent brain cell types, highlighting the potential importance of subtype-specific features for physiology and pathology. We provide a comprehensive overview of various senescent cell types in naturally occurring aging and the most common neurodegenerative disorders. Finally, we critically discuss the potential of adapting senotherapeutics to improve brain health and reduce pathological progression, addressing limitations and future directions for application and development.
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