维生素连接蛋白
整合素
纤维连接蛋白
肽
细胞粘附
粘附
药品
药物输送
癌细胞
靶向给药
癌症研究
细胞
化学
细胞生物学
癌症
纳米技术
药理学
生物化学
材料科学
医学
生物
内科学
有机化学
作者
Hossein Javid,Mahsa Akbari Oryani,Nastaran Rezagholinejad,Ali Esparham,Mahboubeh Tajaldini,Mehdi Karimi‐Shahri
摘要
Abstract RGD peptide can be found in cell adhesion and signaling proteins, such as fibronectin, vitronectin, and fibrinogen. RGD peptides' principal function is to facilitate cell adhesion by interacting with integrin receptors on the cell surface. They have been intensively researched for use in biotechnology and medicine, including incorporation into biomaterials, conjugation to medicinal molecules or nanoparticles, and labeling with imaging agents. RGD peptides can be utilized to specifically target cancer cells and the tumor vasculature by engaging with these integrins, improving drug delivery efficiency and minimizing adverse effects on healthy tissues. RGD‐functionalized drug carriers are a viable option for cancer therapy as this focused approach has demonstrated promise in the future. Writing a review on the RGD peptide can significantly influence how drugs are developed in the future by improving our understanding of the peptide, finding knowledge gaps, fostering innovation, and making drug design easier.
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