胶质瘤
癌变
表皮生长因子受体
信号转导
细胞周期蛋白依赖激酶8
内质网
蛋白激酶B
细胞生物学
癌症研究
跨膜蛋白
高尔基体
生物化学
生物
受体
Notch信号通路
癌症
遗传学
作者
Changning Sun,Yihan Zhang,Zhuangzhi Wang,Can Jin,Junhua Zhang,Yuchao Gu
标识
DOI:10.1016/j.ijbiomac.2024.130055
摘要
Aberrant epidermal growth factor receptor (EGFR) signaling is the core signaling commonly activated in glioma. The transmembrane emp24 protein transport domain protein 2 (TMED2) interacts with cargo proteins involved in protein sorting and transport between endoplasmic reticulum (ER) and Golgi apparatus. In this study, we found the correlation between TMED2 with glioma progression and EGFR signaling through database analysis. Moreover, we demonstrated that TMED2 is essential for glioma cell proliferation, migration, and invasion at the cellular levels, as well as tumor formation in mouse models, underscoring its significance in the pathobiology of gliomas. Mechanistically, TMED2 was found to enhance EGFR-AKT signaling by facilitating EGFR recycling, thereby providing the initial evidence of TMED2's involvement in the membrane protein recycling process. In summary, our findings shed light on the roles and underlying mechanisms of TMED2 in the regulation of glioma tumorigenesis and EGFR signaling, suggesting that targeting TMED2 could emerge as a promising therapeutic strategy for gliomas and other tumors associated with aberrant EGFR signaling.
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