丙型肝炎病毒
CD8型
免疫学
免疫系统
病毒载量
细胞毒性T细胞
T细胞
病毒学
丙型肝炎
医学
病毒
生物
生物化学
体外
作者
Xiaofan Lu,Bingbing Song,Wenjia Weng,Bin Su,Hao Wu,Allen Ka Loon Cheung,Tong Zhang,Yanqing Gao
出处
期刊:Viral Immunology
[Mary Ann Liebert, Inc.]
日期:2022-11-08
卷期号:36 (1): 25-32
被引量:4
标识
DOI:10.1089/vim.2022.0079
摘要
The dysfunction of memory CD8+ T cell cannot be reverted by successful clearance of hepatitis C virus (HCV) after direct-acting antivirals (DAAs) therapy, increasing the risk of reinfection with HCV. Stem cell-like memory T cells (Tscm) with superior properties of long-lasting, self-renewing, and multipotency contribute to the maintenance of immune function. We investigated the impact of HCV infection on CD8+ Tscm, and their possible role in disease progression, by using DAA-naive HCV-infected and human immunodeficiency virus (HIV)/HCV-coinfected cohorts. The distribution of memory CD8+ T cell subsets and the level of T cell immune activation were determined by flow cytometry. Associations between CD8+ Tscm and other memory T cell subsets, HCV viral load, as well as the level of T cell immune activation were analyzed. We observed that the proportion of CD8+ Tscm increased in both HCV and HIV/HCV individuals. The proportion of CD8+ Tscm had positive and negative correlation with CD8+ Tcm (central memory T cells) and CD8+ Tem (effector memory T cell), respectively, representing the contribution of CD8+ Tscm in T cell homeostasis. In addition, higher frequency of CD8+ Tscm indicated lower HCV viral load and less T cell immune activation in HCV infection, which suggested that CD8+ Tscm is likely associated with effective control of HCV replication for protective immunity. Considering the characteristics of Tscm, our current findings provide implications for Tscm-based vaccine design and immunotherapy development to achieve HCV elimination.
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