自噬
细胞生物学
细胞质
泛素
蛋白质聚集
机制(生物学)
化学
生物
生物化学
细胞凋亡
基因
认识论
哲学
作者
Mario Mauthe,Harm H. Kampinga,Mark S. Hipp,Fulvio Reggiori
标识
DOI:10.1016/j.tibs.2022.09.012
摘要
Aggrephagy describes the selective lysosomal transport and turnover of cytoplasmic protein aggregates by macro-autophagy. In this process, protein aggregates and conglomerates are polyubiquitinated and then sequestered by autophagosomes. Soluble selective autophagy receptors (SARs) are central to aggrephagy and physically bind to both ubiquitin and the autophagy machinery, thus linking the cargo to the forming autophagosomal membrane. Because the accumulation of protein aggregates is associated with cytotoxicity in several diseases, a better molecular understanding of aggrephagy might provide a conceptual framework to develop therapeutic strategies aimed at delaying the onset of these pathologies by preventing the buildup of potentially toxic aggregates. We review recent advances in our knowledge about the mechanism of aggrephagy.
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