Sensitive SERS detection of oral squamous cell carcinoma-related miRNAs in saliva via a gold nanohexagon array coupled with hybridization chain reaction amplification

Schematic diagram of HCR amplification strategy for the detection of miRNAs. (A) The preparation process of AuNHs array. (B) Synthesis of SERS probes (C) HCR process and SERS detection of miR-31 and miR-21.