卵磷脂
脂质体
胰岛素
聚电解质
化学
壳聚糖
药物输送
口服
蛋黄卵磷脂
药理学
色谱法
剂型
Zeta电位
材料科学
医学
生物化学
纳米技术
纳米颗粒
内分泌学
有机化学
聚合物
作者
Mayyas Al-Remawi,Amani Elsayed,Ibrahim A. Maghrabi,Mohammad Hamaidi,Nisrein Jaber
标识
DOI:10.1080/10837450.2016.1213745
摘要
In the present work, insulin–chitosan polyelectrolyte complexes associated to lecithin liposomes were investigated as a new carrier for oral delivery of insulin. The preparation was characterized in terms of particle size, zeta potential and encapsulation efficiency. Surface tension measurements revealed that insulin–chitosan polyelectrolyte complexes have some degree of hydrophobicity and should be added to lecithin liposomal dispersion and not the vice versa to prevent their adsorption on the surface. Stability of insulin was enhanced when it was associated to liposomes. Significant reduction of blood glucose levels was noticed after oral administration of liposomal preparation to streptozotocin diabetic rats compared to control. The hypoglycemic activity was more prolonged compared to subcutaneously administered insulin.
科研通智能强力驱动
Strongly Powered by AbleSci AI