Influence of chlorqurine on pulmonary microvascular permeability in rats after smoke inhalation injury

AIM To explore the effect of chlorqurine on pulmonary microvascular permeability in rats after smoke inhalation injury. METHODS Wistar rats were randomly divided into control group, injured groups following smoke inhalation 1, 3, 6, 12, 24 h and treated groups with chlorqurine (10 mg·kg-1, immediately injection intraperitoneally after smoke inhalation) following smoke inhalation 6, 12 h, the content of lung water was measured with drywet weight, the pulmonary microvascular permeability was represented by 131Ilabelled albunim exudation, pulmonary hemorrhage was quantitated with 99mTclabelled erythocytes. RESULTS There were significant increases in the content of lung water and the exudation of 131Ilabelled albumin and reached peak level of 6 hour after smoke inhalation injury (P001), the countered numbers of 99mTclabelled erythocytes was the highest at 1 hour following smoke inhalation and was higher at 24 hours after smoke inhalation compared with control group; there were obvious decreases in the content of lung water, the exudation of 131Ilabelled albumin and the countered numbers of 99mTclabelled erythocytes in chlorqurine treatment group at 6 hours following smoke inhalation compared with injoured group at 6 hours after smoke inhalation (P001). CONCLUSION Chlorqurine might decreased the pulmonary microvascular permeability of rats after smoke inhalation injury.