STUDY OF THE ANTI-DIARRHEA EFFECT OF WENTONGBABUGAO ON MODEL MICE

Objective To study the anti-diarrhea effect of Wentongbabugao on model mice. Methods A diarrhea-model mouse was established by intragastric administration of castro oil.The experimental animals were divided into three groups.The stool characteristics,the number of diarrhea,the weight loss of the mice in six hours,and the skin reaction on which the paste was applied were recorded. Results The number of diarrhea,the weight loss in diarrhea-plus-drug group were less than the diarrhea group and diarrhea-plus-base group,the difference was significant(F=4.20,28.35,q=3.02-5.50;P0.01,0.05).The difference between the diarrhea group and diarrhea-plus-base group was not significant(P0.05).No skin reactions such as flush,rash,blain,or swelling was observed in diarrhea-plus-drug group and diarrhea-plus-base group. Conclusion The Wentongbabugao is effective on anti-diarrhea without irritation to skin.