Objective To observe the clinical effect of hyperbaric oxygenation(HBO) on liver cirrhosis.Methods 86 patients with liver cirrhosis were divided into a HBO group(46 cases)and a control group(40 cases)based on the mated principle of patients conditions.The indices of liver function and fibrotic serology of liver cirrhosis and the changes of B type ultrasound images of portal vein and spleen before and after respective treatment were compared.Results The improvement of liver function(TBil,ALT,ALB)and indices of fibrotic serology of liver cirrhosis(HA,PCIII,ⅣC,LN),and also the decrease of portal vein width and spleen thickness were all more significant in the HBO group than that in the control group.Conclusions Hyperbaric oxygenation could be a useful method for treating patients with liver cirrhosis.