生物
染色质
染色质重塑
组蛋白
细胞生物学
计算生物学
遗传学
表观遗传学
基因
作者
Patric J. Ho,S. Lloyd,Xiaomin Bao
出处
期刊:Development
[The Company of Biologists]
日期:2019-09-30
卷期号:146 (19)
被引量:35
摘要
The BAF (SWI/SNF) chromatin remodeling complex plays a crucial role in modulating spatiotemporal gene expression during mammalian development. Although its remodeling activity was characterized in vitro decades ago, the complex actions of BAF in vivo have only recently begun to be unraveled. In living cells, BAF only binds to and remodels a subset of genomic locations. This selectivity of BAF genomic targeting is crucial for cell-type specification and for mediating precise responses to environmental signals. Here, we provide an overview of the distinct molecular mechanisms modulating BAF chromatin binding, including its combinatory assemblies, DNA/histone modification-binding modules and post-translational modifications, as well as its interactions with proteins, RNA and lipids. This Review aims to serve as a primer for future studies to decode the actions of BAF in developmental processes.
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