生物
辅活化剂
蛋白质精氨酸甲基转移酶5
转录因子
细胞生物学
甲基转移酶
甲基化
遗传学
基因
作者
Samyuktha Suresh,S. Huard,Thierry Dubois
标识
DOI:10.1016/j.tcb.2020.12.010
摘要
Coactivator-associated arginine methyltransferase 1 (CARM1), identified 20 years ago as a coregulator of transcription, is an enzyme that catalyzes arginine methylation of proteins. Beyond its well-established involvement in the regulation of transcription, the physiological functions of CARM1 are still poorly understood. However, recent studies have revealed novel roles of CARM1 in autophagy, metabolism, paraspeckles, and early development. In addition, CARM1 is emerging as an attractive therapeutic target and a drug response biomarker for certain types of cancer. Here, we provide a comprehensive overview of the structure of CARM1 and its post-translational modifications, its various functions, apart from transcriptional coactivation, and its involvement in cancer.
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