2,3‐Dichloro‐5,6‐Dicyano‐1,4‐Benzoquinone (DDQ)‐Mediated Tandem Oxidative Coupling/Intramolecular Annulation/Dehydro‐Aromatization for the Synthesis of Polysubstituted and Fused Pyridines

Abstract A DDQ‐mediated tandem reaction of 1,3‐diarylpropenes and β‐enaminoesters/4‐aminocoumarins is disclosed. It involves oxidative coupling, intramolecular annulation and dehydro‐aromatization reaction, which provides an efficient and mild method for the synthesis of polysubstituted and fused pyridines under metal‐free conditions. magnified image