不良结局途径
优先次序
惊喜
不利影响
结果(博弈论)
钥匙(锁)
毒性
计算机科学
风险分析(工程)
事件(粒子物理)
计算生物学
医学
过程管理
药理学
心理学
业务
生物
计算机安全
内科学
沟通
数理经济学
数学
物理
量子力学
作者
Emma Gustafson,Eva Gijbels,Bruna dos Santos Rodrigues,Vânia Vilas-Boas,Mathieu Vinken
出处
期刊:Methods in molecular biology
日期:2022-01-01
卷期号:: 521-535
被引量:2
标识
DOI:10.1007/978-1-0716-1960-5_20
摘要
Adverse outcome pathways (AOPs) are tools to capture and visualize mechanisms driving toxicological effects. They share a common structure consisting of a molecular initiating event, a series of key events connected by key event relationships and an adverse outcome. Development and evaluation of AOPs ideally comply with guidelines issued by the Organization for Economic Cooperation and Development. AOPs have been introduced for major types of hepatotoxicity, which is not a surprise, as the liver is a frequent target for systemic adversity. Various applications for AOPs have been proposed in the areas of toxicology and chemical risk assessment, in particular in relation to the establishment of quantitative structure-activity relationships, the elaboration of prioritization strategies, and the development of novel in vitro toxicity screening tests and testing strategies.
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