[Pharmacokinetics of Curcumin Ethosomes in Rats in vitro].

OBJECTIVES: To study the oral phamacokinetics of curcumin ethosomes in rats. METHODS: Pharmacokinetics parameters were detected by DAS 2.1.1 software analysis through data of blood concentrations harvested from HPLC after oral administration of curcumin ethosomes in rats. RESULTS: of curcumin ethosomes was 1.4 times larger than that of free curcumin and the relative bioavailability of curcumin ethosomes was 128.2%. CONCLUSION: The curcumin ethosomes can enhance bioavailability, which has a bioinequivalence with free curcumin.