Effects of microRNA and PI3K/AKT signaling pathway on cardiac development

MiRNA can regulate cell proliferation and differentiation,and promote the development of organisms.Phosphoinositide 3-kinase/protein kinase B(PI3K/AKT) signaling pathway plays an important role in cell proliferation and differentiation,and also in organ and organization development.Studies concerning miRNA and PI3K/AKT signaling pathways in cardiac development and their relationship might help explain the pathogenesis of cardiac malformations and related diseases. Key words: MicroRNA;  Phosphoinosidde 3-kinase/protein kinase B;  Signaling pathway;  Cardiac development