动力学分辨率
化学
部分
双功能
对映体
对映选择合成
角鲨胺
催化作用
分辨率(逻辑)
轴手性
手性(物理)
立体化学
有机化学
有机催化
手征异常
粒子物理学
物理
人工智能
费米子
计算机科学
Nambu–Jona Lasinio模型
作者
Liying Cui,Youming Wang,Fan Zhang,Zhengming Li,Zhenghong Zhou
标识
DOI:10.1002/adsc.201900292
摘要
Abstract An efficient kinetic resolution of axially chiral 2‐nitrovinyl biaryls was realized through organocatalytic asymmetric Michael addition of acetone to the nitroolefin moiety. Under the catalysis of a chiral thiophosphinamide derived from (1 R ,2 R )‐1,2‐diphenylethane‐1,2‐diamine, racemic 2‐nitrovinyl biaryls were converted into highly enantiomer‐enriched 2‐nitrovinyl biaryls in 13–44% yields and a pair of separable Michael addition products bearing both axial and central chiralities in excellent stereocontrol. This represents the first successful application of asymmetric Michael addition of nitroolefins in kinetic resolution of axially chiral biaryls. magnified image
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