CXCR4型
弥漫性大B细胞淋巴瘤
淋巴瘤
趋化因子受体
医学
癌症研究
骨髓
趋化因子
肿瘤科
生物
病理
内科学
受体
作者
Huarui Du,Lei Gao,Jing Luan,Hangfan Zhang,Taiwu Xiao
出处
期刊:Acta Haematologica
[S. Karger AG]
日期:2019-01-01
卷期号:142 (2): 64-70
被引量:9
摘要
Diffuse large B cell lymphoma (DLBCL), an aggressive cancer of the B cells, is the most common subtype of non-Hodgkin lymphoma (NHL) worldwide. In China, the cases of DLBCL increase yearly. C-X-C chemokine receptor 4 (CXCR4) has been implicated in the migration and trafficking of malignant B cells in several hematological malignancies, and only a few reports have been published on the role of CXCR4 in the metastasis of DLBCL. This review summarizes the relevant perspectives on the functional mechanism, prognostic significance, and therapeutic applications of the CXCL12/CXCR4 axis in DLBCL, in particular DLBCL with bone marrow involvement.
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