Oxidative lipoprotein markers predict poor functional outcome in patients with minor stroke or transient ischaemic attack

Background and purpose Oxidative stress plays an important role in acute ischaemic stroke. However, the association of oxidative lipoprotein markers, including oxidized low‐density lipoprotein (ox LDL ), ox LDL :high‐density lipoprotein ( HDL ) and ox LDL :low‐density lipoprotein ( LDL ), with functional outcome of minor stroke or transient ischaemic attack ( TIA ) remains unclear. We aimed to investigate the association between oxidative lipoprotein markers and poor functional outcome in patients with minor stroke or TIA . Methods All patients with minor stroke or TIA were recruited from the Clopidogrel in High‐Risk Patients With Acute Non‐Disabling Cerebrovascular Events ( CHANCE ) trial. The poor functional outcome included modified Rankin Scale ( mRS ) score 2–6 and 3–6 at 90‐day and 12‐month follow‐up. Multivariate logistic regression was used to investigate the associations of ox LDL , ox LDL : HDL and ox LDL : LDL with poor functional outcome. Results Among 3019 patients included in this study, the median (interquartile range) ox LDL , ox LDL : HDL and ox LDL : LDL were 13.96 (6.65–28.81), 4.52 (2.08–9.32) and 11.73 (5.27–24.85) μg/dL, respectively. After adjusted for confounding factors, patients in the highest ox LDL quartile had a higher proportion of mRS score 2–6 at 90 days [hazard ratio ( HR ), 1.78; 95% confidence interval ( CI ), 1.26–2.52] and 12 months ( HR , 1.42; 95% CI , 1.01–1.99), and mRS score 3–6 at 90 days ( HR , 1.98; 95% CI , 1.29–3.04) and 12 months ( HR , 1.77; 95% CI , 1.09–2.89) when compared with the lowest ox LDL quartile ( P < 0.05). Similar results were found for ox LDL : HDL and ox LDL : LDL . Conclusions Higher levels of oxidative lipoprotein markers are independent predictors of poor functional outcome in patients with minor stroke or TIA at 90 days and 12 months.