Photoredox Catalyzed Trifluoromethyl Radical‐Triggered Trifunctionalization of 5‐HexenenitrilesviaCyano Migration

Abstract A photoredox catalyzed trifluoromethyl radical‐triggered trifunctionalization of 5‐hexenenitriles via cyano group migration is reported. The cyano group migration is of high chemo‐selectivity even in the presence of aryl or heteroaryl groups as competitors. This protocol provides a facile access to a broad scope of CF 3 ‐containing compounds with high molecular complexity and functional group diversity. The success of gram‐scale reaction and the versatility of products in derivative synthesis illustrate the potential value of this transformation in synthetic chemistry. magnified image