Cu(OTf)2-catalyzed C3 aza-Friedel–Crafts alkylation of indoles with N,O-acetals

An efficient approach to access functionalized indole derivatives has been developed through Cu(OTf) 2 -catalyzed C3 aza-Friedel–Crafts alkylation of substituted indoles 5a–5m, N -methyl-pyrrole with linear N , O -acetals 4a–4l.