医学
肾病
药效学
耐受性
药代动力学
发病机制
自身抗体
免疫学
免疫系统
肾脏疾病
内科学
药理学
胃肠病学
内分泌学
不利影响
抗体
糖尿病
作者
Jonathan Barratt,Billy Hour,Laura Kooienga,Shane Roy,Bruce A. Schwartz,Ammad Ahmad Siddiqui,Júlio César Tolentino,Sunil Iyer,Colleen Stromatt,Aaron N. Endsley,Johnny Lo,A. Glicklich
标识
DOI:10.1016/j.ekir.2022.01.121
摘要
IgA nephropathy (IgAN) is an autoimmune disease with no approved treatments. A critical step in IgAN pathogenesis is the production of galactose-deficient IgA1 (Gd-IgA1) leading to the generation of anti-Gd-IgA1 autoantibodies and the formation of immune complexes that result in kidney inflammation and damage. A Proliferation-Inducing Ligand (APRIL), a soluble factor that regulates B cell differentiation, proliferation and survival of plasma cells, and IgA class-switching is elevated in patients with IgAN.
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