Temperature-responsive P(NIPAM-co-NHMA)-grafted organic-inorganic hybrid hollow mesoporous silica nanoparticles for controlled drug delivery

Hollow mesoporous silica nanoparticles (HMSN) have been widely studied as drug delivery carriers due to their high drug loading capacity in the internal cavity. In this study, monodisperse and temperature-responsive hollow mesoporous silica nanoparticles ([email protected](NIPAM-co-NHMA)) were synthesized and investigated. HMSN and [email protected](NIPAM-co-NHMA) were characterized by SEM, TEM, FT-IR, TGA, XRD and nitrogen adsorption-desorption isotherms. The results showed that the cross-linked temperature-sensitive polymer P(NIPAM-co-NHMA) was grafted onto the surface of HMSN. Subsequently, using puerarin (PUE) as the drug model, the results demonstrated that the [email protected](NIPAM-co-NHMA) had an excellent loading efficiency and exhibited excellently temperature-sensitive release behavior. Furthermore, the biocompatibility and stability of HMSN and [email protected](NIPAM-co-NHMA) were studied by MTT assay and hemolysis assay, the results indicated [email protected](NIPAM-co-NHMA) possessed excellent biocompatibility and stability. Thus, we have successfully synthesized [email protected](NIPAM-co-NHMA), and the drug release is temperature-responsive, which can realize controlled drug release.