前额叶皮质
神经科学
兴奋性突触后电位
光遗传学
突触后电位
抑制性突触后电位
社会失败
电生理学
心理学
运动前神经元活动
丘脑
生物
化学
内科学
医学
认知
受体
作者
Fang Li,Hanjie Wang,Lianghui Meng,Meiying Chen,Xuefeng Zheng,Yuqing Hui,Danlei Liu,Yifei Li,Keman Xie,Jifeng Zhang,Guoqing Guo
出处
期刊:Research Square - Research Square
日期:2022-03-17
标识
DOI:10.21203/rs.3.rs-1434398/v1
摘要
Abstract The mediodorsal thalamus (MD) is interconnected with the medial prefrontal cortex (mPFC) and works together to promote some forms of behavioral flexibility. But the relationship between the MD-mPFC circuit and depression is remain unknown. Here, we show that in male susceptible mice, MDGLU neuronal calcium signaling activity is reduced. Chemogenetic inhibition of MDGLU neuronal in male C57BL/J mice resulted in behavioral abnormalities, whereas in susceptible mice, activation of MDGLU neuronal ameliorated depression-like behavior. Brain slice electrophysiology and fiber optic recordings reveal elevated excitability of mPFCGLU neurons in male susceptible mice. Furthermore, we found that in susceptible mice, mPFCGLU neurons exhibited decreased inhibitory postsynaptic currents and unchanged excitatory postsynaptic currents, and increased E/I ratios, whereas activation of MDGLU neurons restored these electrophysiological properties abnormal. Optogenetic activation of the MD-mPFC circuit ameliorates depression-like behaviors in susceptible mice. Taken together, these data demonstrate that the MD-mPFC circuit controls distinct aspects of depression-like behavior.
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