化学
铱
转移加氢
催化作用
钳子运动
组合化学
乙醇
不对称氢化
溶剂
有机化学
对映选择合成
钌
作者
Qian Lu,Xixia Tang,Yulei Wang,Guixia Liu,Zheng Huang
标识
DOI:10.1002/cjoc.202100868
摘要
Comprehensive Summary The use of a chiral (NCP)Ir complex as the precatalyst allowed for the discovery of asymmetric transfer hydrogenation of diaryl ketones with ethanol as the hydrogen source and solvent. This reaction was applicable to various ortho ‐substituted diaryl keontes, affording benzhydrols in good yields and enantioselectivities. This protocol could be carried out in a gram scale under mild reaction conditions. The utility of the catalytic system was highlighted by the synthesis of the key precursor of ( S )‐neobenodine.
科研通智能强力驱动
Strongly Powered by AbleSci AI