化学
表面改性
异氰
电化学
戒指(化学)
组合化学
环肽
氨基甲酸酯
环胺
立体化学
肽
有机化学
催化作用
电极
生物化学
物理化学
作者
Feijun Wang,Kevin J. Frankowski
标识
DOI:10.1021/acs.joc.1c02534
摘要
We developed an electrochemical carboamidation sequence that affords either cyclic β-amidoamine products via direct functionalization or linear hydroxybisamide products via a ring opening pathway. The reaction pathway was dependent on the nature of the N-acyl activating group, with carbamate groups favoring direct isocyanide addition to the N-acyliminium ion intermediate and the benzoyl activating group favoring the ring opening-functionalization pathway. Both protocols are one-pot reaction sequences, have general applicability, and lead to peptide-like products of greatly increased molecular complexity.
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