脂肪性肝炎
脂肪肝
肝硬化
肝星状细胞
炎症
纤维化
脂肪变性
获得性免疫系统
免疫系统
酒精性肝炎
内科学
医学
酒精性肝病
免疫学
生物
疾病
病理
作者
Marina Nati,David Haddad,Andreas L. Birkenfeld,Christian A. Koch,Triantafyllos Chavakis,Antonios Chatzigeorgiou
标识
DOI:10.1007/s11154-016-9339-2
摘要
The low grade inflammatory state present in obesity promotes the progression of Non-Alcoholic Fatty Liver Disease (NAFLD). In Non-Alcoholic Steatohepatitis (NASH), augmented hepatic steatosis is accompanied by aberrant intrahepatic inflammation and exacerbated hepatocellular injury. NASH is an important disorder and can lead to fibrosis, cirrhosis and even neoplasia. The pathology of NASH involves a complex network of mechanisms, including increased infiltration of different subsets of immune cells, such as monocytes, T-lymphocytes and neutrophils, to the liver, as well as activation and in situ expansion of liver resident cells such as Kupffer cells or stellate cells. In this review, we summarize recent advances regarding understanding the role of the various cells of the innate and adaptive immunity in NASH development and progression, and discuss possible future therapeutic options and tools to interfere with disease progression.
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