Microwave Assisted Synthesis of Some Bioactive 1,8- Naphthyridinyl Heterocycles and Development of New Synthetic Methodologies in Organic Synthesis

1Introduction Organic synthesis is a powerful discipline, which forms the basis for numerous other areas of research in chemistry and chemical biology. Organic chemists and chemical research in general are under great demand to develop environmentally benign technologies for the synthesis of well-defined precursors and target molecules.It is at this juncture that the microwave assisted technique comes into the picture.Microwave assisted organic reactions have blossomed into an important tool with a variety of applications,particularly after the development of Microwave-induced Organic Reaction Enhancement (MORE) chemistry techniques[1-3]. These techniques require open vessels with little or no solvents and are free of the risk of explosion. MORE chemistry reactions are extremely fast, cleaner than conventional reactions and lead to higher atom economy. Because of short time requirement, ease of workability and eco-friendliness, microwaves provide an alternative green approach to environmentally unacceptable procedures using toxic and expensive reagents. Recently, the use of inorganic solid supports as catalysts[4] have been developed for solvent-free reactions resulting in higher selectivity, milder conditions and easy handling. Clay catalyzed organic reactions are gaining importance owing to their inexpensive nature and special catalytic attributes in heterogeneous reactions[5].