Parenteral nutrition (PN), including lipids, in high‐risk or poorly nourished critically ill patients is indicated when enteral nutrition is contraindicated; however, soybean oil–based PN can stimulate proinflammatory processes. Fish oil (FO) is generally less inflammatory and has recently been shown to be active in the resolution of inflammatory processes. In this study, we look at whether the use of a blended intravenous fat emulsion that includes soybean, medium‐chain triglycerides, olive oil, and FO confers clinical benefits in critically ill patients.