位阻效应
背景(考古学)
溶剂化
折叠(DSP实现)
蛋白质折叠
化学
生物物理学
功能(生物学)
生物
细胞生物学
生物化学
立体化学
电气工程
工程类
古生物学
溶剂
作者
Caitlin Davis,Martin Gruebele,Shahar Sukenik
标识
DOI:10.1016/j.sbi.2017.09.003
摘要
The cellular environment is highly diverse and capable of rapid changes in solute composition and concentrations. Decades of protein studies have highlighted their sensitivity to solute environment, yet these studies were rarely performed in situ. Recently, new techniques capable of monitoring proteins in their natural context within a live cell have emerged. A recurring theme of these investigations is the importance of the often-neglected cellular solvation environment to protein function. An emerging consensus is that protein processes in the cell are affected by a combination of steric and non-steric interactions with this solution. Here we explain how protein surface area and volume changes control these two interaction types, and give recent examples that highlight how even mild environmental changes can alter cellular processes.
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