纤维化
病态的
组织重塑
心脏纤维化
心室重构
长非编码RNA
增强子
医学
生物
非编码RNA
核糖核酸
病理
遗传学
内科学
心力衰竭
基因
炎症
转录因子
作者
Rudi Micheletti,Isabelle Plaisance,Brian J. Abraham,Alexandre Sarre,Ching-Chia Ting,Michael Alexanian,Daniel Maric,Damien Maison,Mohamed Nemir,Richard A. Young,Blanche Schroen,Arantxa González,Samir Ounzain,Thierry Pedrazzini
标识
DOI:10.1126/scitranslmed.aai9118
摘要
as a cardiac fibroblast-enriched super-enhancer-associated lncRNA that represents an attractive therapeutic target to reduce the pathological development of cardiac fibrosis in response to MI and prevent adverse remodeling in the damaged heart.
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