Porphyrin-Containing MOFs and COFs as Heterogeneous Photosensitizers for Singlet Oxygen-Based Antimicrobial Nanodevices

Visible-light irradiation of porphyrin and metalloporphyrin dyes in the presence of molecular oxygen can result in the photocatalytic generation of singlet oxygen (1O2). This type II reactive oxygen species (ROS) finds many applications where the dye, also called the photosensitizer, is dissolved (i.e., homogeneous phase) along with the substrate to be oxidized. In contrast, metal-organic frameworks (MOFs) are insoluble (or will disassemble) when placed in a solvent. When stable as a suspension, MOFs adsorb a large amount of O2 and photocatalytically generate 1O2 in a heterogeneous process efficiently. Considering the immense surface area and great capacity for gas adsorption of MOFs, they seem ideal candidates for this application. Very recently, covalent-organic frameworks (COFs), variants where reticulation relies on covalent rather than coordination bonds, have emerged as efficient photosensitizers. This comprehensive mini review describes recent developments in the use of porphyrin-based or porphyrin-containing MOFs and COFs, including nanosized versions, as heterogeneous photosensitizers of singlet oxygen toward antimicrobial applications.