Metformin again? Atheroprotection mediated by macrophage AMPK and ATF1

Metformin is a biguanide that has been used as a frontline treatment for type 2 diabetes (T2DM) over the past 60 years, though its medicinal roots date back to medieval times.While new medications have emerged in recent years, metformin remains the most widely prescribed anti-diabetic drug.Despite this, the molecular