医学
眼科
光学相干层析成像
视网膜
糖尿病性视网膜病变
视网膜
光学相干断层摄影术
脉络膜
神经丛
视网膜病变
前瞻性队列研究
荧光血管造影
外科
光学
糖尿病
内分泌学
物理
作者
Jaekyun Moon,Itika Garg,Ying Cui,Raviv Katz,Ying Zhu,Rongrong Le,Yifan Lu,Edward S. Lu,Cassie A. Ludwig,Tobias Elze,David M. Wu,Dean Eliott,Joan W. Miller,Leo A. Kim,Deeba Husain,Demetrios G. Vavvas,John B. Miller
标识
DOI:10.1136/bjophthalmol-2021-319540
摘要
Pathological myopia (PM) is a leading cause of blindness worldwide. We aimed to evaluate microvascular and chorioretinal changes in different stages of myopia with wide-field (WF) swept-source (SS) optical coherence tomography angiography (OCTA).This prospective cross-sectional observational study included 186 eyes of 122 patients who had undergone imaging between November 2018 and October 2020. Vessel density (VD) and vessel skeletonised density (VSD) of superficial capillary plexus, deep capillary plexus and whole retina, as well as foveal avascular zone parameters, retinal thickness (RT) and choroidal thickness (CT), were calculated.This study evaluated 75 eyes of 48 patients with high myopia (HM), 43 eyes of 31 patients with mild to moderate myopia and 68 eyes of 53 age-matched controls. Controlling for age and the presence of systemic hypertension, we found that HM was associated with decrease in VD and VSD in all layers on 12×12 mm² scans. Furthermore, HM was associated with a VD and VSD decrease in every Early Treatment Diabetic Retinopathy Study grid, with a larger decrease temporally (βVD=-0.39, βVSD=-10.25, p<0.01). HM was associated with decreased RT and CT. Reduction in RT was outside the macular region, while reduction in CT was in the macular region.Using WF SS-OCTA, we identified reduction in microvasculature and structural changes associated with myopia. Decrease in VD and VSD was greater in the temporal quadrant, and reductions in RT and CT were uneven across the retina. Further work may help identify risk factors for the progression of PM and associated vision-threatening complications.
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