固体脂质纳米粒
药物输送
纳米载体
消炎药
纳米医学
药品
医学
体内
毒品携带者
脂质体
生物利用度
纳米颗粒
姜黄素
作者
Kézia Cristine Barbosa Ferreira,Ana Beatriz Caribé dos Santos Valle,Camila Quinetti Paes,Guilherme Diniz Tavares,Frederico Pittella
出处
期刊:Pharmaceutics
[MDPI AG]
日期:2021-09-13
卷期号:13 (9): 1454-
被引量:2
标识
DOI:10.3390/pharmaceutics13091454
摘要
The main function of the skin is to protect the body from the external environment. However, the skin can undergo inflammatory processes, due to genetic, hormonal, or environmental factors. When the defense system is overloaded, there is an increase in pro-inflammatory mediators and reactive oxygen species (ROS), which results in skin disorders. Among the substances used to treat these inflammatory processes, many natural substances with anti-inflammatory and antioxidant properties are being studied: nature is yet an abundant source to obtain diverse pharmacological actives. The treatment of skin diseases is usually focused on topical application, as it reduces the risk of systemic side effects and prevents drug degradation by first-pass metabolism. Thus, the properties of drug delivery vehicles can facilitate or inhibit its permeation. Due to the hydrophobic nature of the skin, a promising strategy to improve dermal drug penetration is the use of lipid-based nanoparticles, such as nanostructured lipid carriers (NLC). Therefore, in this review, we present NLC as a tool to improve dermal administration of natural substances with anti-inflammatory properties.
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