EPH受体A2
肝细胞癌
癌症研究
医学
索拉非尼
促红细胞生成素肝细胞(Eph)受体
肝癌
生物
出处
期刊:Molecular and Cellular Oncology
[Informa]
日期:2021-04-14
卷期号:8 (3): 1910009-1910009
标识
DOI:10.1080/23723556.2021.1910009
摘要
Identifying critical drivers of oncogenesis and tumor progression is essential for developing effective hepatocellular carcinoma (HCC) therapeutics. Our recent findings has demonstrated that targeting Ephrin Receptor A2 (EPHA2) suppresses HCC initiation and progression by dual inhibition of the Protein Kinase B (AKT) and Signal Transducer and Activator of Transcription 3 (STAT3) signaling.
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