医学
内科学
结直肠癌
胃肠病学
化疗
新辅助治疗
肿瘤科
癌症
乳腺癌
作者
Chong Zhang,Xiangyu Wang,Jiahao Han,Rui Zhang,Zhenmei Chen,Yitong Li,Xiaochen Ma,Zhiyong Guo,Jia Fan,Jinhong Chen
摘要
Abstract Background This study investigated the correlation between tumor regression grade (TRG) score and Immunoscore, and prognostic values of TRG score and a risk score in colorectal cancer liver metastases (CRLMs) patients after neoadjuvant chemotherapy. Methods Patients undergoing neoadjuvant chemotherapy from 2014 to 2019 were selected. TRG score and Immunoscore were evaluated in 200 CRLMs. A risk score combining TRG score, Immunoscore, and clinical risk score (CRS) was defined and divided patients into the low‐, medium‐, and high‐risk groups. Differences in relapse‐free survival (RFS) and overall survival (OS) between groups were determined. Results The densities of CD3 + and CD8 + immune cells were higher in TRG1–3 group than in TRG4–5 group, and the ratio of high Immunoscores was higher in TRG1–3 group than in TRG4–5 group (60.0% vs. 15.8%, p < 0.001). Patients in TRG1–3 group had significantly longer RFS and OS than those in TRG4–5 group. The low‐risk group shows a significantly higher 2‐year RFS and 5‐year OS rate than the medium‐ and high‐risk group (RFS: 59.9%, 36.2%, and 6.4%, p < 0.001; OS: 82.0%, 41.0%, and 16.9%, p < 0.001). Conclusion TRG score may be proposed to evaluate the prognosis of neoadjuvant chemotherapy and may be used for predicting the postoperative survival of CRLMs.
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