140 teeth from 120 patients with apical periodontitis which needed root canal treatment were selected and divided into Vitapex group and FC group.The clinical effect level and endodontic interappointment pain(EIP)were observed and compared after root canal disinfection.Compared with FC group,Vitapex group had a lower EIP rate and better root canal disinfection effect.Vitapex paste is a ideal root canal disinfected agent.